N-803 Boosts CD34+ Progenitor-Derived NK Cell Expansion and Functionality
Adding N-803 to NK Cell Therapy has Potential to Improve Cancer Immunotherapy
“While allogeneic NK cell therapy is a promising and potentially paradigm-shifting approach for cancer immunotherapy, there are still considerable challenges remaining in the field,” said
Key findings from the study performed under the guidance of Prof.
- Anktiva induces HPC-NK cell proliferation in a dose-dependent manner;
- Treatment with Anktiva increases IFN-γ production in CD34+ hematopoietic progenitor-derived NK cells (HPC-NK) stimulated with leukemia cells lines and improves killing of primary AML samples from patients;
- Anktiva improves serial killing properties of HPC-NK cells against leukemia as measured by live cell imaging with single cell resolution;
- Anktiva increases CXCL10 production and improves long-term HPC-NK cell-mediated killing in ovarian cancer spheroids, an ovarian cancer model which mimics three-dimensional growth of ovarian cancer in vivo;
- HPC-NK cells combined with Anktiva and nanogam (human immunoglobulins) show anti-tumor effects in a human ovarian cancer mouse model;
Together, these data point to the clear potential of Anktiva™ to improve efficacy of NK cell-based immunotherapies by promoting HPC-NK cell expansion and functionality.
ImmunityBio has established three fundamental platforms to drive long term immunological memory. These include first-in-class antibody cytokine fusion proteins, synthetic immune modulators, and second-generation vaccine vector platforms.
ImmunityBio’s lead cytokine infusion protein, a novel interleukin-15 (IL-15) superagonist complex (Anktiva™), has received Breakthrough Therapy Designation from the
ImmunityBio is also developing therapies, including vaccines, for the prevention and treatment of HIV, influenza, and the coronavirus SARS-CoV-2 with its second-generation human adenovirus (hAd5) vaccine platform.
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