42% Of Patents Exhibited A Response, With Two Complete Responses In A Phase 1 Study Of 12 Patients With A Patient In Complete Remission 10 Years After Failing Transplant Therapy For Hodgkin’s Lymphoma, And A Second Patient In Complete Remission 2 Years After Failing Transplant Therapy In Multiply Myeloma
The data published in the journal Oncotarget by investigators at
“Our study was designed to assess safety and preliminary evidence
of efficacy in patients with relapsed, refractory hematological
malignancies whose disease recurred after autologous hematopoietic cell
transplantation (AHCT). In this heavily pretreated patient population
that has a particularly poor prognosis, we demonstrated
safety with minimal toxicity and showed preliminary evidence of
efficacy, taking advantage of the unique properties of natural killer
(NK) cells as an immunotherapeutic agent,” said
Dr. Keating continued, “In this clinical study completed in 2015 of 12 patients with lymphoma and multiple myeloma who had relapsed after AHCT for refractory/relapsed disease, we report encouraging results with four patients (33%) currently alive and two complete responses, one for over two years and the second for over 10 years and conclude that aNK cell therapy warrants further clinical investigation.”
Dr. Soon-Shiong continued, “We believe our product portfolio of novel off-the-shelf NK cell therapies is unique in offering a more uniform, consistent and optimized product potency with minimal toxicity and we remain focused on translating these unique advantages to patient care as rapidly as possible.”
aNK Cell Therapy Platform
NantKwest’s aNK cell therapy platform is being developed as an allogeneic, off-the-shelf therapy, offering a potent, standardized, uniform and consistent product, further optimized to enhance the key capability of natural killer cells to directly target and kill cancer cells. This novel cell therapy is currently in an ongoing Phase II clinical trial in Merkel cell carcinoma and is a critical, foundational component in the company’s recently launch NANT Cancer Vaccine clinical trial program.
About NANT Cancer Vaccine
The NANT Cancer Vaccine is the first combination immunotherapy protocol to orchestrate the delivery of metronomic low dose radiation and chemotherapy with molecularly informed tumor associated antigen vaccines and natural killer cells, to activate the innate and adaptive immune system and to induce immunogenic cell death. By inducing immunogenic cell death and protecting as well as enhancing the innate and adaptive immune system, the NANT Cancer Vaccine seeks to attain long-term sustainable remission of multiple tumor types with lower toxicity and higher efficacy than current standards of care.
NantKwest’s unique NK cell-based platform, with the capacity to grow active killer cells as a biological cancer therapy, has been designed to induce cell death against cancer or infected cells by three different modes of action: (1) Direct killing using activated NK cells (aNK) that release toxic granules directly into the cell through cell to cell contact, (2) Antibody-mediated killing using haNKs, which are NK cells engineered to incorporate a high affinity receptor that binds to an administered antibody, enhancing the cancer cell killing effect of that antibody, and (3) Targeted activated killing using taNKs, which are NK cells engineered to incorporate chimeric antigen receptors (CARs) to target tumor-specific antigens found on the surface of cancer cells.
Our aNK, haNK and taNK platform addresses certain limitations of T cell
therapies including the reduction of risk of serious "cytokine storms"
reported after T cell therapy. As an “off-the-shelf” therapy,
By leveraging an integrated and extensive genomics and transcriptomics
discovery and development engine, together with a pipeline of multiple,
clinical-stage, immuno-oncology programs that include a Phase 2 trial
for a rare form of melanoma and the planned initiation of a clinical
trial of NK cells targeted to breast cancer, we believe